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"George Ensor, drawing by John Comerford George Ensor J.P. (17 December 1769 – 3 December 1843) was an eminent Irish author and lawyer. Ensor was born in Ardress, County Armagh and lived in Ardress house, Ireland and educated at the Royal School, Armagh followed by Trinity College Dublin. He was called to the Irish Bar in 1792. He married Esther Weld (sister of famous Irish explorer, author and painter Isaac Weld) on 7 January 1804. His father, George Ensor, and uncle, John Ensor, were architects who designed much of Merrion Square, Parnell Square, the Rotunda of the Rotunda Hospital, now the Ambassador Theatre (Dublin), the Hotel Saint Georgethecastlehotelgroup.com and the Castle Hotelthecastlehotelgroup.com \- all in Dublin. They originated from Coventry and Wilnecote, England. George (Senior) was the first of the 'Irish' Ensors and John the first of the Rollesby Hall/New Zealand Ensors. He was a well- known political writer and patriot, author of at least twenty books of educational and Irish interest, and the father-in-law of J. P. Prendergast the historian. He was a friend of Daniel O'Connell, Jeremy Bentham and James Mill. He accompanied John Stuart Mill (aged 14) to France in 1820. Was a grand juror and High Sheriff (1806) of County Armagh and died on 3 December 1843 at the family home, Ardress House, now property of the National Trust.nationaltrust.org.uk Books *The Independent Man (1806) *On National Government (2 vols., 1810) *National Education (1811) *Defects of the English Laws and Tribunals (1812). Marvin described this book as "a rambling, desultory, fault-finding, ill digested volume, in which the author finds little to praise and much to blame".Marvin's Legal Bibliography (1847) p 296. For other reviews, see (1813) 72 Monthly Review 174; K, "Review" (1813) 10 Belfast Monthly Magazine 58 and 138; (1814) 6 Critical Review 10. See also Holdsworth, A History of English Law, Methuen, 1966, vol 13, p 495. Copy of this book by Ensor: Google Books. Ensor was influenced by Romilly.Radzinowicz, Leon. A History of English Criminal Law and Its Administration from 1750. Macmillan. 1948. vol 1. p 366. *Observations on the present state of Ireland (1814) * An Inquiry Concerning the Population of Nations containing a Refutation of Mr. Malthus's Essay on Population (1918) *Address to the People of Ireland on the Degradation and Misery of their Country (1823) *A Defence of the Irish and the Means of their Redemption (1825) DNB DIW DIH DUB *Of property and of its equal distribution as promoting virtue, population, abundance *Letters showing the inutility, and exhibiting the absurdity, of what is rather fantastically termed "the new Reformation" *Irish Affairs at the Close of 1825 (1827) *Anti-Union, Ireland as She Ought to Be (1831) *Before and After the Reform Bill (1842) *Principles of Morality *The Poor and their relief 1823 References Oxford Biography Index entry George Ensor Ensor, George (1769-1843), political writer Oxford Biography Index Number 101008822 External links * Oxford DNB * Ulster Biographies * On National Government, Volume 2 (Free Ebook from Internet Archive) *Irish Affairs at the Close of 1825 (Free Ebook from Internet Archive) * The poor and their relief (Free Ebook from Google Books) * An Inquiry Concerning the Population of Nations: Containing a Refutation of Mr. Malthus's Essay on Population (1818) (Free Ebook from Google Books) * New York Public Library Category:1769 births Category:1843 deaths Category:Education writers Category:Irish political writers Category:Irish lawyers Category:18th-century Irish people Category:19th-century Irish people Category:People from County Armagh "
"Michal Smejkal (born 21 February 1986) is a former Czech footballer. He played for FC Viktoria Plzeň, FK Teplice, FK Mladá Boleslav, SK Slavia Prague, Okzhetpes and Dukla Prague. Career In March 2015, Smejkal signed for Kazakhstan Premier League side FC Okzhetpes. He joined Dukla Prague in January 2016, signing a contract until the end of the 2016–17 season. References External links * Official website Category:1986 births Category:Living people Category:Czech footballers Category:Czech Republic youth international footballers Category:Czech Republic under-21 international footballers Category:FC Viktoria Plzeň players Category:FK Teplice players Category:FK Mladá Boleslav players Category:SK Slavia Prague players Category:Association football defenders Category:FK Dukla Prague players Category:Association football forwards "
"Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition (1:1,000,000), in which the bones have lesions, inflammation, and pain. It is called multifocal because it can appear in different parts of the body, primarily bones, and osteomyelitis because it is very similar to that disease, although CRMO appears to be without any infection. The definition of CRMO is evolving. Many doctors and articles described CRMO as an autoimmune disease that has symptoms similar to osteomyelitis, but without the infection. Some doctors thought CRMO was related to SAPHO syndrome. Research now classifies CRMO as an inherited autoinflammatory disease but have yet to isolate the exact gene or other causes responsible for it. Classification Due to its inflammatory nature, its recurrent outbreaks, and its lack of any known pathogen, CRMO has been reclassified as an autoinflammatory disease. This particular classification encompasses both hereditary types (familial Mediterranean fever, mevalonate kinase deficiency, TNF receptor associated periodic syndrome, cryopyrin-associated periodic syndrome, Blau syndrome, pyogenic sterile arthritis, pyoderma gangrenosum and acne syndrome, CRMO) and multifactorial disorders (Crohn's and Behçet's diseases). CRMO is no longer considered an autoimmune but rather an inherited, autoinflammatory disease. Symptoms The main symptom is pain. Diagnosis CRMO/CNO is a diagnosis of exclusion. This means that other diseases must be ruled out before the diagnosis can be made. Generally, many tests are required, such as blood tests, x-rays, bone scans, MRI and often a bone biopsy. Treatment CRMO/CNO is generally treated by a specialist doctor (paediatric rheumatologist) who has experience with patients with CRMO/CNO. Goals of treatment of CRMO/CNO include: * Reduce inflammation * Prevent bone damage and bone deformities * Decrease pain CRMO/CNO is different for each patient. Not every child responds to every treatment. Your doctor may need to try several medications before finding the one that works for your child. In severe cases, doctors may combine medications to treat the disease. Your doctor will work with you and your child to help find the best treatment. For some CRMO/CNO patients, the disease can be managed with non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are the first line treatment. However, if NSAIDs are not effective, or if your child does not tolerate NSAIDs well, second line treatments are available. First line treatments include Naproxen (Aleve), Celecoxib (Celebrex) Meloxicam (Mobic), Piroxicam (Feldene), Indomethacin (Indocin), Diclofenac (Voltaren). Second line treatments include corticosteroids (Prednisone/Prednisolone), Methotrexate (Otrexup, Rasuvo, Trexall), Sulfasalazine (Azulfidine), Pamidronate (Aredia), Zolendronic Acid (Zometa), Adalimumab (Humira), Etanercept (Enbrel), Infliximab (Remicade). These medications are also used in children with other inflammatory and/or bone conditions. Side effects may occur while taking these medications. Prognosis Prognosis will depend on your child's individual disease and response to treatment. It is best to discuss the prognosis with your child's pediatric rheumatologist. Cause Some specialists believe they have discovered a link between CRMO with a rare allele of marker D18S60, resulting in a haplotype relative risk (HRR) of 18. Other experts found that "mutations in LPIN2 cause a syndromic form of chronic recurrent multifocal osteomyelitis known as Majeed syndrome, while mutations in pstpip2 cause a murine form of the disorder. The roles played by LPIN2 and the human homolog of pstpip2, PSTPIP2, in the cause of chronic recurrent multifocal osteomyelitis are uncertain. The professional theories seem to be moving in the direction of an inherited gene. Epidemiology CRMO was once considered strictly a childhood disease, but adults have been diagnosed with it. The affected tends to range from 4 to 14 years old, with 10 as the median age. As stated above, CRMO occurs 1:1,000,000 and primarily in girls with a 5:1 ratio. That means out of six million, there will probably be 5 girls and 1 boy with the condition. =Majeed syndrome= Majeed syndrome is an autoinflammatory disorder consisting of CRMO, congenital dyserythropoietic anemia, and neutrophilic dermatosis. To date, two unrelated families with Majeed syndrome have been reported. Mutations in LPIN2 have been found in both families. Here we report a third consanguineous family with Majeed syndrome with a novel mutation. The patient, a 3-year-old Arabic girl, had hepatosplenomegaly and anemia as a neonate. At age 15 months, she developed recurrent episodes of fever and multifocal osteomyelitis. In addition, bone marrow aspiration demonstrated significant dyserythropoiesis (defective red cell formation), suggesting Majeed syndrome. Coding sequences and splice sites of LPIN2 were sequenced in the patient and her mother. A homozygous single-basepair change was detected in the donor splice site of exon 17 (c.2327+1G>C) in the patient; her mother was heterozygous at this site. These data confirm the role of LPIN2 mutations in the cause of Majeed syndrome. Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis, uncommon childhood diseases of unknown cause, occurred in three children (two brothers and a female cousin). Their parents are consanguineous, and the clinical course of their illness was similar. The two brothers also had Sweet syndrome. The association of Sweet syndrome with chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia in this family suggests that these rare conditions may be interrelated. Notes References * * Further reading *Great Ormond Street Hospital for Children NHS *GeneReview/NIH/UW entry on Majeed syndrome (Chronic recurrent multifocal osteomyelitis, chronic dyserythropoietic anemia, and transient inflammatory dermatosis) *"A link to many more professional articles and journals." * * External links Category:Bacterial diseases Category:Skeletal disorders "