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"Filmstaden main gate (2008) Filmstaden main gate (c.1925) Filmstaden was a film studio situated in Råsunda, Solna Municipality in Stockholm, Sweden. History Filmstaden was once one of the most modern film studios in Europe. It was built in 1919–1920 on the basis of designs by Swedish architect Ebbe Crone (1885-1960). It was owned and operated by SF Studios (Svensk Filmindustri), the main Swedish film producer at the time. Some 400 movies have been created at Filmstaden. The first movie to be filmed at Filmstaden was The Phantom Carriage (Körkarlen. 1921) by director Victor Sjöström. Practically all Swedish actors and film directors of the 20th century had some connection with Filmstaden. In 1969, Svensk Filmindustri left Filmstaden and the studios were used by small film producers, production of television dramas and the Riksteatern Theatre. One of the last major films to partly have been filmed at Filmstaden was The Emigrants (Utvandrarna. 1971) directed by Jan Troell. Most of the buildings were quite well preserved until the beginning of the 21st century when Filmstaden had to make way for a housing development. However, some buildings have been renovated and SF Studios has moved its headquarters back into a former studio building. References Other sources *Birkeland, Anders (2000) Filmstaden 1919-2000 (Stockholm: Streiffert) External links *Filmstaden website *SF Studios website Category:Swedish film studios Category:Buildings and structures in Stockholm Category:1920 establishments in Sweden "
"Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene. Function This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Pathology Micrograph showing CADASIL with a Notch 3 immunostain. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mutations in NOTCH3 have also been identified in a Turkish family with Alzheimer's disease. Adult Notch3 knock-out mice show incomplete neuronal maturation in the spinal cord dorsal horn, resulting in permanently increased nociceptive sensitivity. Mutations in NOTCH3 are associated to lateral meningocele syndrome. Pharmaceutical target Notch3 is being investigated as a target for anti- cancer drugs, as it is overexpressed in several types of cancers. Early clinical trials of Pfizer's PF-06650808, an anti-Notch3 antibody linked to a cytotoxic drug, showed efficacy against solid tumors.http://adcreview.com/pfizer-adc-development-overview-2016/ References Further reading External links * "
"The Permian Dunkard Group (Pd) is an area of rock, Early Permian in age, in the south of Ohio, southwestern Pennsylvania, West Virginia and the hilltops of the Georges Creek Basin of Maryland. In Ohio, it is found primarily in Washington County. It is notable for being one of the few areas of Permian sediment east of the Mississippi River. In addition, it is the youngest surface rock in the state of Ohio. Description It consists of red and green shale, siltstone, and sandstone, with thin lenticular beds of argillaceous limestone and thin beds of impure coal The base of the layer contains thick-bedded, white conglomeratic sandstone. The layer's thickness is greater than 200 feet in Maryland. The fossils found in the Dunkard Group are similar to ones found in Texas and Oklahoma of similar age. Fossil content * Dimetrodon * Ctenospondylus * Archaeothyris * Edaphosaurus * Eryops * Xenacanthus * Ophiacodon * Diploceraspis * Diplocaulus * Baldwinonus * Protorothyris * Diadectes * Isodectes * Sagenodus * Brachydectes * Phlegethontia See also * Geology of Pennsylvania References Further reading * Category:Permian System of North America Category:Sandstone formations of the United States Category:Shale formations of the United States Category:Coal formations Category:Limestone formations Category:Siltstone formations Category:Silurian United States Category:Silurian Ohio Category:Silurian geology of Pennsylvania Category:Silurian West Virginia Category:Geologic groups of Ohio Category:Geologic groups of Pennsylvania Category:Geologic groups of West Virginia "